|ZFIN ID: ZDB-PUB-170124-3|
MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin
Gu, W., Zhan, H., Zhou, X.Y., Yao, L., Yan, M., Chen, A., Liu, J., Ren, X., Zhang, X., Liu, J.X., Liu, G.
|Source:||FEBS letters 591(3): 513-526 (Journal)|
|Registered Authors:||Liu, Jing-xia|
|Keywords:||VE-cadherin, endothelial inflammation, miR-22, vascular development|
|PubMed:||28112401 Full text @ FEBS Lett.|
Gu, W., Zhan, H., Zhou, X.Y., Yao, L., Yan, M., Chen, A., Liu, J., Ren, X., Zhang, X., Liu, J.X., Liu, G. (2017) MicroRNA-22 regulates inflammation and angiogenesis via targeting VE-cadherin. FEBS letters. 591(3):513-526.
ABSTRACTThe vascular endothelial (VE)-cadherin functions as an endothelial barrier protein controlling endothelial permeability and leukocyte transmigration. Developmental studies indicate that VE-cadherin also plays a vital role in angiogenesis. MicroRNA-22 plays important roles in cardiovascular diseases including cardiac hypertrophy and heart failure. We identified that miR-22 interacts with VE-cadherin mRNA. Overexpression of miR-22 in endothelial cells increases the synthesis of pro-inflammatory cytokines. Injection of miR-22 results in increased myeloperoxidase activity in the mouse lungs. Moreover, miR-22 injection into the fluorescent-labeled transgenic zebrafish Tg(fli1:EGFP) embryos caused defective vascular development in the dorsal and intersegmental vessels, and vascular markers were significantly suppressed in these embryos. Our studies demonstrate that the conserved targeting of VE-cadherin by miR-22 regulates endothelial inflammation, tissue injury, and angiogenesis. This article is protected by copyright. All rights reserved.