ZFIN ID: ZDB-PUB-170124-2
Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish
Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J.
Date: 2017
Source: Environmental toxicology and chemistry   36(8): 2139-2146 (Journal)
Registered Authors: Liu, Jing
Keywords: Enantioselective biotransformation, Enantioselective toxicity, Metals, Pyrethroids, Zebrafish
MeSH Terms:
  • Animals
  • Biodegradation, Environmental
  • Biotransformation
  • Drug Synergism
  • Insecticides/chemistry
  • Insecticides/metabolism
  • Insecticides/toxicity*
  • Male
  • Metals, Heavy/chemistry
  • Metals, Heavy/metabolism
  • Metals, Heavy/toxicity*
  • Pyrethrins/chemistry
  • Pyrethrins/metabolism
  • Pyrethrins/toxicity*
  • Stereoisomerism
  • Water Pollutants, Chemical/chemistry
  • Water Pollutants, Chemical/metabolism
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish/metabolism*
PubMed: 28112430 Full text @ Environ. Toxicol. Chem.
ABSTRACT
Co-occurrence of pyrethroids and metals in watersheds has been reported previously to pose great risk to aquatic species. Pyrethroids are a class of chiral insecticides that have been shown to have enantioselective toxicity and biotransformation. However, the influence of metals on enantioselectivity of pyrethroids has not yet been evaluated. In this study, the effects of cadmium (Cd), copper (Cu) and lead (Pb) on the enantioselective toxicity and metabolism of cis-bifenthrin (cis-BF) were investigated in zebrafish at environmentally relevant concentrations. The addition of Cd, Cu or Pb significantly increased the mortality of zebrafish in racemate and R-enantiomer of cis-BF treated groups. In rac-cis-BF or 1R-cis-BF treated groups, the addition of Cd, Cu or Pb caused a decrease in enantiomer fraction (EF) and an increased ratio of R-enantiomer residues in zebrafish. In 1S-cis-BF treated groups, co-exposure to Cd led to a lower EF and decreased residue levels of S-enantiomer. Additionally, co-exposure to the three metals resulted in different biodegradation characteristics of each enantiomer accompanied with differential changes in the expression of cytochrome P450 (CYP) 1, CYP2 and CYP3 genes, which might be responsible for the enantioselective biodegradation of cis-BF in zebrafish. These results suggest that the influence of coexistent metals should be considered in the ecological risk assessment of chiral pyrethroids in aquatic environments. This article is protected by copyright. All rights reserved.
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