PUBLICATION
Heritable expansion of the genetic code in mouse and zebrafish
- Authors
- Chen, Y., Ma, J., Lu, W., Tian, M., Thauvin, M., Yuan, C., Volovitch, M., Wang, Q., Holst, J., Liu, M., Vriz, S., Ye, S., Wang, L., Li, D.
- ID
- ZDB-PUB-161211-6
- Date
- 2017
- Source
- Cell Research 27(2): 294-297 (Journal)
- Registered Authors
- Vriz, Sophie
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Genetic Code*
- Inheritance Patterns/genetics*
- Mice, Transgenic
- Zebrafish/genetics*
- PubMed
- 27934867 Full text @ Cell Res.
Citation
Chen, Y., Ma, J., Lu, W., Tian, M., Thauvin, M., Yuan, C., Volovitch, M., Wang, Q., Holst, J., Liu, M., Vriz, S., Ye, S., Wang, L., Li, D. (2017) Heritable expansion of the genetic code in mouse and zebrafish. Cell Research. 27(2):294-297.
Abstract
The genetic code can be expanded to encode unnatural amino acids (Uaas) by introducing an orthogonal tRNA/aminoacyl-tRNA synthetase (aaRS) pair to decode a stop codon. Initially developed in Escherichia coli1, this strategy has been proven generally applicable in eukaryotic cells2 and in generating transgenic invertebrates capable of Uaa incorporation, including Caenorhabditis elegans3 and Drosophila melanogaster4.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping