PUBLICATION
Ginsenoside Re Inhibits Osteoclast Differentiation in Mouse Bone Marrow-Derived Macrophages and Zebrafish Scale Model
- Authors
- Park, C.M., Kim, H.M., Kim, D.H., Han, H.J., Noh, H., Jang, J.H., Park, S.H., Chae, H.J., Chae, S.W., Ryu, E.K., Lee, S., Liu, K., Liu, H., Ahn, J.S., Kim, Y.O., Kim, B.Y., Soung, N.K.
- ID
- ZDB-PUB-161209-6
- Date
- 2016
- Source
- Molecules and cells 39(12): 855-861 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Macrophages/cytology
- Macrophages/drug effects*
- Bone Marrow Cells/cytology
- Bone Marrow Cells/drug effects*
- PubMed
- 27927007 Full text @ Mol. Cells
Abstract
Ginsenosides, which are the active materials of ginseng, have biological functions that include anti-osteoporotic effects. Aqueous ginseng extract inhibits osteoclast differentiation induced by receptor activator of NF-κB ligand (RANKL). Aqueous ginseng extract produces chromatography peaks characteristic of ginsenosides. Among these peaks, ginsenoside Re is a major component. However, the preventive effects of ginsenoside Re against osteoclast differentiation are not known. We studied the effect of ginsenoside Re on osteoclast differentiation, RANKL-induced tartrate-resistant acid phosphatase (TRAP) activity, and formation of multinucleated osteoclasts in vitro. Ginsenoside Re hampered osteoclast differentiation in a dose-dependent manner. In an in vivo zebrafish model, aqueous ginseng extract and ginsenoside Re had anti-osteoclastogenesis effects. These findings suggest that both aqueous ginseng extract and ginsenoside Re prevent bone resorption by inhibiting osteoclast differentiation. Ginsenoside Re could be important for promoting bone health.
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