ZFIN ID: ZDB-PUB-161008-11
Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
Liu, J., Zhu, Y., Luo, G.Z., Wang, X., Yue, Y., Wang, X., Zong, X., Chen, K., Yin, H., Fu, Y., Han, D., Wang, Y., Chen, D., He, C.
Date: 2016
Source: Nature communications   7: 13052 (Journal)
Registered Authors: Chen, Kai, He, Chuan
Keywords: Chemical modification, DNA methylation, Embryogenesis
Microarrays: GEO:GSE76740
MeSH Terms:
  • Animals
  • DNA/chemistry*
  • DNA Methylation/genetics*
  • Deoxyadenosines/chemistry*
  • Embryonic Development/genetics*
  • Genome
  • Repetitive Sequences, Nucleic Acid/genetics
  • Swine/embryology*
  • Swine/genetics
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed: 27713410 Full text @ Nat. Commun.
DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.