PUBLICATION
Understanding the regulation of vertebrate hematopoiesis and blood disorders: big lessons from a small fish
- Authors
- Robertson, A.L., Avagyan, S., Gansner, J.M., Zon, L.I.
- ID
- ZDB-PUB-160913-9
- Date
- 2016
- Source
- FEBS letters 590(22): 4016-4033 (Review)
- Registered Authors
- Robertson, Anne, Zon, Leonard I.
- Keywords
- blood disorders, hematopoietic stem cells, zebrafish
- MeSH Terms
-
- Animals
- Hematologic Diseases/genetics*
- Hematologic Diseases/pathology
- Hematopoiesis/genetics*
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/metabolism
- Humans
- Zebrafish/genetics*
- Zebrafish/growth & development
- PubMed
- 27616157 Full text @ FEBS Lett.
Citation
Robertson, A.L., Avagyan, S., Gansner, J.M., Zon, L.I. (2016) Understanding the regulation of vertebrate hematopoiesis and blood disorders: big lessons from a small fish. FEBS letters. 590(22):4016-4033.
Abstract
Hematopoietic stem cells (HSCs) give rise to all differentiated blood cells. Understanding the mechanisms that regulate self-renewal and lineage specification of HSCs is key for developing treatments for many human diseases. Zebrafish have emerged as an excellent model for studying vertebrate hematopoiesis. This review will highlight the unique strengths of zebrafish and important findings that have emerged from studies of blood development and disorders using this system. We discuss recent advances in our understanding of hematopoiesis, including the origin of HSCs, molecular control of their development, and key signaling pathways involved in their regulation. We highlight significant findings from zebrafish models of blood disorders and discuss their application for investigating stem cell dysfunction in disease and for developing new therapeutics. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping