PUBLICATION
The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes
- Authors
- Rastegar, S., Strähle, U.
- ID
- ZDB-PUB-160810-10
- Date
- 2016
- Source
- Advances in genetics 95: 195-216 (Chapter)
- Registered Authors
- Rastegar, Sepand, Strähle, Uwe
- Keywords
- Enhancer, Epigenetics, Genetics, Transcription regulation, Zebrafish, cis-Regulatory modules
- MeSH Terms
-
- Animals
- Gene Expression Regulation, Developmental/genetics*
- Genome/genetics*
- Humans
- Regulatory Sequences, Nucleic Acid/genetics
- Transcription, Genetic/genetics
- Zebrafish/genetics*
- PubMed
- 27503358 Full text @ Adv. Genet.
Citation
Rastegar, S., Strähle, U. (2016) The Zebrafish as Model for Deciphering the Regulatory Architecture of Vertebrate Genomes. Advances in genetics. 95:195-216.
Abstract
Despite enormous progress to map cis-regulatory modules (CRMs), like enhancers and promoters in genomes, elucidation of the regulatory landscape of the developing embryo remains a challenge. The zebrafish embryo with its experimental virtues has a great potential to contribute to this endeavor. However, so far progress remained behind expectation. We discuss here available methods and their limitations and how the zebrafish embryo could contribute in the future to unravel the wiring of the vertebrate genome.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping