PUBLICATION
Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
- Authors
- Rajan, V., Dellaire, G., Berman, J.N.
- ID
- ZDB-PUB-160729-18
- Date
- 2016
- Source
- Methods in molecular biology (Clifton, N.J.) 1451: 171-89 (Chapter)
- Registered Authors
- Berman, Jason, Rajan, Vinothkumar
- Keywords
- Meganuclease, Patient-derived xenograft, Transgenesis, Xenograft
- MeSH Terms
-
- Animals
- Animals, Genetically Modified/genetics
- Animals, Genetically Modified/metabolism*
- Animals, Genetically Modified/physiology*
- Carcinogenesis/metabolism
- Carcinogenesis/pathology
- Disease Models, Animal
- Heterografts/metabolism
- Heterografts/pathology
- Humans
- Leukemia/metabolism*
- Leukemia/pathology*
- Mutation/genetics
- Zebrafish/genetics
- Zebrafish/metabolism*
- Zebrafish/physiology*
- PubMed
- 27464808 Full text @ Meth. Mol. Biol.
Citation
Rajan, V., Dellaire, G., Berman, J.N. (2016) Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models. Methods in molecular biology (Clifton, N.J.). 1451:171-89.
Abstract
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping