ZFIN ID: ZDB-PUB-160729-18
Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
Rajan, V., Dellaire, G., Berman, J.N.
Date: 2016
Source: Methods in molecular biology (Clifton, N.J.)   1451: 171-89 (Chapter)
Registered Authors: Berman, Jason, Rajan, Vinothkumar
Keywords: Meganuclease, Patient-derived xenograft, Transgenesis, Xenograft
MeSH Terms:
  • Animals
  • Animals, Genetically Modified/genetics
  • Animals, Genetically Modified/metabolism*
  • Animals, Genetically Modified/physiology*
  • Carcinogenesis/metabolism
  • Carcinogenesis/pathology
  • Disease Models, Animal
  • Heterografts/metabolism
  • Heterografts/pathology
  • Humans
  • Leukemia/metabolism*
  • Leukemia/pathology*
  • Mutation/genetics
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish/physiology*
PubMed: 27464808 Full text @ Meth. Mol. Biol.
The zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.