|ZFIN ID: ZDB-PUB-160729-18|
Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models
Rajan, V., Dellaire, G., Berman, J.N.
|Source:||Methods in molecular biology (Clifton, N.J.) 1451: 171-89 (Chapter)|
|Registered Authors:||Berman, Jason, Rajan, Vinothkumar|
|Keywords:||Meganuclease, Patient-derived xenograft, Transgenesis, Xenograft|
|PubMed:||27464808 Full text @ Meth. Mol. Biol.|
Rajan, V., Dellaire, G., Berman, J.N. (2016) Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models. Methods in molecular biology (Clifton, N.J.). 1451:171-89.
ABSTRACTThe zebrafish is a widely accepted model to study leukemia. The major advantage of studying leukemogenesis in zebrafish is attributed to its short life cycle and superior imaging capacity. This chapter highlights using transgenic- and xenograft-based models in zebrafish to study a specific leukemogenic mutation and analyze therapeutic responses in vivo.
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