ZFIN ID: ZDB-PUB-160729-15
Methodologies for Inducing Cardiac Injury and Assaying Regeneration in Adult Zebrafish
Wang, J., Poss, K.D.
Date: 2016
Source: Methods in molecular biology (Clifton, N.J.)   1451: 225-35 (Chapter)
Registered Authors: Poss, Kenneth D., Wang, Jinhu
Keywords: Ablation, Cardiomyocyte, Heart, Regeneration, Surgery, Zebrafish
MeSH Terms:
  • Animals
  • Biological Assay/methods*
  • Heart/physiology*
  • Heart/physiopathology*
  • Heart Injuries/metabolism
  • Heart Injuries/pathology
  • Heart Injuries/physiopathology*
  • Heart Ventricles/metabolism
  • Heart Ventricles/pathology
  • Heart Ventricles/physiopathology
  • Myocardium/metabolism
  • Myocardium/pathology
  • Myocytes, Cardiac/cytology
  • Myocytes, Cardiac/physiology
  • Regeneration/genetics
  • Regeneration/physiology*
  • Signal Transduction/physiology
  • Wound Healing/physiology
  • Zebrafish
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 27464811 Full text @ Meth. Mol. Biol.
The zebrafish has emerged as an important model organism for understanding the cellular and molecular mechanisms of tissue regeneration. Adult zebrafish efficiently replace cardiac muscle after partial resection of their ventricle, or after transgenic ablation of cardiomyocytes. Here, we describe methodology for inducing these injuries and assaying indicators of regeneration.