ZFIN ID: ZDB-PUB-160726-1
The Regenerative Potential of the Vertebrate Retina: Lessons from the Zebrafish
Ng, J., Currie, P., Jusuf, P. R.
Date: 2014
Source: Regenerative Biology of the Eye : 49-82 (Chapter)
Registered Authors: Currie, Peter D., Jusuf, Patricia, Ng, Jeremy
Keywords: none
MeSH Terms: none
PubMed: none Full text @ Regenerative Biology of the Eye
The regenerative potential, forward/reverse genetic capabilities and technical advantages of the zebrafish make it an ideal model for studying signals and mechanisms that drive retinal regeneration. Here, we describe the different cellular sources of regeneration in zebrafish, with a particular emphasis on Müller glia cells, as well as the individual signalling pathways that specifically co-ordinate the different phases of regeneration. Because the same cells are also generated developmentally, a comparison between developmental and regenerative processes is of particular benefit to identify the extent to which we can drive developmental mechanisms to improve adult regenerative responses. Given the recent identification of many conserved signalling pathways using zebrafish developmental studies, we can now use this model system to assess their involvement during regeneration. Finally, identifying similarities and differences between zebrafish and amniotic vertebrates allows us to distinguish between the intrinsic capacity and extrinsic signals that can improve regeneration. Thus, we aim to highlight data obtained from the zebrafish vertebrate model and how this information can and has contributed to and directed mammalian research.