PUBLICATION
Use of Coronary Ultrasound Imaging to Evaluate Ventricular Function in Adult Zebrafish
- Authors
- Ernens, I., Lumley, A.I., Devaux, Y., Wagner, D.R.
- ID
- ZDB-PUB-160622-6
- Date
- 2016
- Source
- Zebrafish 13(6): 477-480 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Cardiomyopathies/diagnostic imaging*
- Cardiomyopathies/physiopathology
- Disease Models, Animal
- Heart Ventricles/diagnostic imaging*
- Male
- Ultrasonography*
- Ventricular Function*
- Zebrafish/physiology*
- PubMed
- 27326768 Full text @ Zebrafish
Citation
Ernens, I., Lumley, A.I., Devaux, Y., Wagner, D.R. (2016) Use of Coronary Ultrasound Imaging to Evaluate Ventricular Function in Adult Zebrafish. Zebrafish. 13(6):477-480.
Abstract
So far, imaging of the adult zebrafish heart and assessment of heart failure in adult zebrafish have been very limited. Here, we describe a new method for in vivo imaging of the hypertrabeculated heart of the adult zebrafish using miniaturized cardiac ultrasound catheters obtained from the cardiac catheterization laboratory. This method allows the observation of the ventricle of zebrafish and the assessment of ventricular diameters during diastole and systole, as well as heart rate and fractional shortening. Significant changes in these parameters were detected through the use of an adult zebrafish heart failure model induced by chronic anemia. This imaging technique opens the door to detailed in vivo analysis of the adult heart failure phenotype in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping