PUBLICATION
Neural circuits that drive startle behavior, with a focus on the Mauthner cells and spiral fiber neurons of fishes
- Authors
- Hale, M.E., Katz, H.R., Peek, M.Y., Fremont, R.T.
- ID
- ZDB-PUB-160616-5
- Date
- 2016
- Source
- Journal of neurogenetics 30(2): 89-100 (Review)
- Registered Authors
- Hale, Melina
- Keywords
- Escape, giant neurons, hindbrain, startle, zebrafish
- MeSH Terms
-
- Animals
- Behavior, Animal/physiology*
- Fishes/physiology*
- Neural Pathways/physiology*
- Neurons/physiology*
- Reflex, Startle/physiology*
- PubMed
- 27302612 Full text @ J. Neurogenet.
Citation
Hale, M.E., Katz, H.R., Peek, M.Y., Fremont, R.T. (2016) Neural circuits that drive startle behavior, with a focus on the Mauthner cells and spiral fiber neurons of fishes. Journal of neurogenetics. 30(2):89-100.
Abstract
Startle behaviors are rapid, high-performance motor responses to threatening stimuli. Startle responses have been identified in a broad range of species across animal diversity. For investigations of neural circuit structure and function, these behaviors offer a number of benefits, including that they are driven by large and identifiable neurons and their neural control is simple in comparison to other behaviors. Among vertebrates, the best-known startle circuit is the Mauthner cell circuit of fishes. In recent years, genetic approaches in zebrafish have provided key tools for morphological and physiological dissection of circuits and greatly extended understanding of their architecture. Here we discuss the startle circuit of fishes, with a focus on the Mauthner cells and associated interneurons called spiral fiber neurons and we add new observations on hindbrain circuit organization. We also briefly review and compare startle circuits of several other taxa, paying particular attention to how movement direction is controlled.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping