PUBLICATION
Retina regeneration in zebrafish
- Authors
- Wan, J., Goldman, D.
- ID
- ZDB-PUB-160610-2
- Date
- 2016
- Source
- Current opinion in genetics & development 40: 41-47 (Review)
- Registered Authors
- Goldman, Dan, Wang,Jin
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Differentiation/genetics*
- Cell Proliferation/genetics*
- Humans
- Nerve Regeneration/genetics*
- Neuroglia/metabolism
- Retina/growth & development*
- Retina/injuries
- Retina/pathology
- Stem Cells/metabolism
- Zebrafish/genetics
- Zebrafish/growth & development
- PubMed
- 27281280 Full text @ Curr. Opin. Genet. Dev.
Citation
Wan, J., Goldman, D. (2016) Retina regeneration in zebrafish. Current opinion in genetics & development. 40:41-47.
Abstract
Unlike mammals, zebrafish are able to regenerate a damaged retina. Key to this regenerative response are Müller glia that respond to retinal injury by undergoing a reprogramming event that allows them to divide and generate a retinal progenitor that is multipotent and responsible for regenerating all major retinal neuron types. The fish and mammalian retina are composed of similar cell types with conserved function. Because of this it is anticipated that studies of retina regeneration in fish may suggest strategies for stimulating Müller glia reprogramming and retina regeneration in mammals. In this review we describe recent advances and future directions in retina regeneration research using zebrafish as a model system.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping