ZFIN ID: ZDB-PUB-160525-4
Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography
Zhang, J., Liu, J., Wang, L.M., Li, Z.Y., Yuan, Z.
Date: 2017
Source: Journal of biophotonics   10(6-7): 878-886 (Journal)
Registered Authors: Liu, Jing, Zhang, Jian
Keywords: Janus microsphere, contrast enhancement, optical coherence tomography, retroreflective-type
MeSH Terms:
  • Animals
  • Contrast Media/chemistry*
  • Female
  • Imaging, Three-Dimensional*
  • Liver/diagnostic imaging
  • Male
  • Mice, Nude
  • Microspheres
  • Phantoms, Imaging
  • Tomography, Optical Coherence*
  • Zebrafish
PubMed: 27218690 Full text @ J. Biophotonics
Optical coherence tomography (OCT) is a well-developed technology that utilizes near-infrared light to reconstruct three-dimensional images of biological tissues with micrometer resolution. Improvements of the imaging contrast of the OCT technique are able to further widen its extensive biomedical applications. In this study, Janus microspheres were developed and used as a positive contrast agent for enhanced OCT imaging. Phantom and ex vivo liver tissue experiments as well as in vivo animal tests were conducted, which validated that Janus microspheres, as a novel type of OCT tracer, were very effective in improving the OCT imaging contrast. Working principle and SEM image of Janus microsphere (top). Enhanced OCT imaging (bottom) of Janus microspheres in zebrafish stomach (blue dash line) and sinusoids (green arrows) of nude liver.