PUBLICATION

Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis

Authors
Luo, N., Li, H., Xiang, B., Qiao, L., He, J., Ji, Y., Liu, Y., Li, S., Lu, R., Li, Y., Meng, W., Wu, Y., Xu, H., Mo, X.
ID
ZDB-PUB-160505-3
Date
2016
Source
Scientific Reports   6: 25300 (Journal)
Registered Authors
Li, Yu, Mo, Xianming, Xu, Hong
Keywords
Cell proliferation, Developmental neurogenesis
MeSH Terms
  • Animals
  • Cell Proliferation/drug effects*
  • Gene Expression
  • Gene Knockdown Techniques
  • Gene Knockout Techniques
  • Neurogenesis*
  • Neurons/physiology*
  • Syndecan-4/genetics
  • Syndecan-4/metabolism*
  • Zebrafish/embryology*
PubMed
27143125 Full text @ Sci. Rep.
Abstract
Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan (HSPG), plays significant role in the formation of focal adhesions and interacts with many growth factors to regulate cell migration and neural induction. Here, we show the new roles of syndecan-4(syn4) in zebrafish embryonic neurogenesis. Syn4 is broadly and dynamically expressed throughout the early stages of embryonic development. Knockdown of syn4 increases the expression of the marker genes of multiple types of neural cells. The increased expression of the marker genes is resulted from excessive proliferation of the neural cells. In addition, disrupting syn4 expression results in truncated and multiple aberrant branching of caudal primary (CaP) axons. Collectively, these data indicate that Syn4 suppresses the cellular proliferation during neurogenesis and is crucial for the formation of CaP axons during zebrafish embryogenesis.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes