Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis
- Luo, N., Li, H., Xiang, B., Qiao, L., He, J., Ji, Y., Liu, Y., Li, S., Lu, R., Li, Y., Meng, W., Wu, Y., Xu, H., Mo, X.
- Scientific Reports 6: 25300 (Journal)
- Registered Authors
- Li, Yu, Mo, Xianming, Xu, Hong
- Cell proliferation, Developmental neurogenesis
- MeSH Terms
- Cell Proliferation/drug effects*
- Gene Expression
- Gene Knockdown Techniques
- Gene Knockout Techniques
- 27143125 Full text @ Sci. Rep.
Luo, N., Li, H., Xiang, B., Qiao, L., He, J., Ji, Y., Liu, Y., Li, S., Lu, R., Li, Y., Meng, W., Wu, Y., Xu, H., Mo, X. (2016) Syndecan-4 modulates the proliferation of neural cells and the formation of CaP axons during zebrafish embryonic neurogenesis. Scientific Reports. 6:25300.
Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan (HSPG), plays significant role in the formation of focal adhesions and interacts with many growth factors to regulate cell migration and neural induction. Here, we show the new roles of syndecan-4(syn4) in zebrafish embryonic neurogenesis. Syn4 is broadly and dynamically expressed throughout the early stages of embryonic development. Knockdown of syn4 increases the expression of the marker genes of multiple types of neural cells. The increased expression of the marker genes is resulted from excessive proliferation of the neural cells. In addition, disrupting syn4 expression results in truncated and multiple aberrant branching of caudal primary (CaP) axons. Collectively, these data indicate that Syn4 suppresses the cellular proliferation during neurogenesis and is crucial for the formation of CaP axons during zebrafish embryogenesis.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes