ZFIN ID: ZDB-PUB-160417-2
Cell migration during heart regeneration in zebrafish
Tahara, N., Brush, M., Kawakami, Y.
Date: 2016
Source: Developmental dynamics : an official publication of the American Association of Anatomists   245(7): 774-87 (Review)
Registered Authors: Kawakami, Yasuhiko, Tahara, Naoyuki
Keywords: Cardiomyocytes, Endocardial endothelial and vascular endothelial cells, Epicardial cells, Heart regeneration, Local cell migration, Zebrafish
MeSH Terms:
  • Animals
  • Cell Movement/genetics
  • Cell Movement/physiology
  • Heart/physiology*
  • Myocytes, Cardiac/cytology*
  • Myocytes, Cardiac/metabolism
  • Myocytes, Cardiac/physiology
  • Regeneration/physiology*
  • Zebrafish
  • Zebrafish Proteins/metabolism
PubMed: 27085002 Full text @ Dev. Dyn.
Zebrafish possess the remarkable ability to regenerate injured hearts as adults, which contrasts the very limited ability in mammals. Although very limited, mammalian hearts do in fact have measurable levels of cardiomyocyte regeneration. Therefore, elucidating mechanisms of zebrafish heart regeneration would provide information of naturally occurring regeneration to potentially apply to mammalian studies, in addition to addressing this biologically interesting phenomenon in itself. Studies over the last 13 years have identified processes and mechanisms of heart regeneration in zebrafish. After heart injury, pre-existing cardiomyocytes dedifferentiate, enter the cell cycle and repair the injured myocardium. This process requires interaction with epicardial cells, endocardial cells and vascular endothelial cells. Epicardial cells envelope the heart, while endocardial cells make up the inner lining of the heart. They provide paracrine signals to cardiomyocyte to regenerate the injured myocardium, which is vascularized during heart regeneration. In addition, accumulating results suggest that local migration of these major cardiac cell types have roles in heart regeneration. In this review, we summarize the characteristics of various heart injury methods used in the research community, and regeneration of the major cardiac cell types. Then, we discuss local migration of these cardiac cell types and immune cells during heart regeneration.