PUBLICATION

Zebrafish as a Model for Human Ciliopathies

Authors
Song, Z., Zhang, X., Jia, S., Yelick, P.C., Zhao, C.
ID
ZDB-PUB-160330-10
Date
2016
Source
Journal of genetics and genomics = Yi chuan xue bao   43: 107-20 (Review)
Registered Authors
Yelick, Pamela C., Zhao, Chengtian
Keywords
Cilia, Ciliopathy, Disease model, Zebrafish
MeSH Terms
  • Animals
  • Cilia/metabolism
  • Cilia/pathology
  • Ciliopathies*/genetics
  • Ciliopathies*/metabolism
  • Ciliopathies*/pathology
  • Disease Models, Animal*
  • Humans
  • Zebrafish*
PubMed
27020031 Full text @ J. Genet. Genomics
Abstract
Cilia, microtubule-based structures found on the surface of almost all vertebrate cells, play an array of diverse biological functions. Abnormal ciliary axonemal structure and function can result in a class of genetic disorders that are collectively termed ciliopathies. Model organisms, including Chlamydomonas reinhardtii and Caenorhabditis elegans have been widely used to study the complex genetic basis of ciliopathies. Here, we review the advantages of the zebrafish as a vertebrate model for human ciliopathies. We summarize the features of zebrafish cilia, and the major findings and contributions of the zebrafish model in recent studies of human ciliopathies. We also discuss the new genome editing approaches being efficiently used in zebrafish, and the exciting prospects of these approaches in modeling human ciliopathies.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes