PUBLICATION
Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis
- Authors
- Avagyan, S., Zon, L.I.
- ID
- ZDB-PUB-160329-3
- Date
- 2016
- Source
- Human gene therapy 27(4): 287-94 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Blood/metabolism*
- Genetic Testing
- Hematologic Diseases/pathology*
- Hematopoiesis*
- Humans
- Reverse Genetics
- Zebrafish/blood
- Zebrafish/genetics*
- Zebrafish/physiology*
- PubMed
- 27018965 Full text @ Hum. Gene Ther.
Citation
Avagyan, S., Zon, L.I. (2016) Fish to Learn: Insights into Blood Development and Blood Disorders from Zebrafish Hematopoiesis. Human gene therapy. 27(4):287-94.
Abstract
Since its introduction since early 1980s, the zebrafish (Danio rerio) has become an invaluable vertebrate animal model system to study many human disorders in almost all systems, from hepatic and brain pathology, to autoimmune and psychiatric disorders. Hematopoiesis between zebrafish and mammals is highly conserved, making the zebrafish an attractive model to study hematopoietic development and blood disorders. Unique attributes of the zebrafish include the ability to perform large-scale genetic and chemical screens in vivo, study development at the cellular level and use transgenic fish to dissect mechanisms of disease or drug effects. This review summarizes major discoveries that helped define molecular control of hematopoiesis in vertebrates and specific contributions from studies in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping