PUBLICATION
Endothelial-to-hematopoietic transition: Notch-ing vessels into blood
- Authors
- Kanz, D., Konantz, M., Alghisi, E., North, T.E., Lengerke, C.
- ID
- ZDB-PUB-160326-1
- Date
- 2016
- Source
- Annals of the New York Academy of Sciences 1370(1): 97-108 (Review)
- Registered Authors
- Alghisi, Elisa, Konantz, Martina, Lengerke, Claudia, North, Trista
- Keywords
- GPR56, Notch, endothelial-to-hematopoietic transition, hematopoiesis, hematopoietic stem cells
- MeSH Terms
-
- Animals
- Cell Differentiation/physiology
- Cell Lineage
- Endothelial Cells/cytology*
- Endothelial Cells/metabolism
- Hematopoiesis/physiology
- Hematopoietic Stem Cells/cytology*
- Hematopoietic Stem Cells/metabolism
- Humans
- Receptors, Notch/metabolism*
- Signal Transduction/physiology*
- Zebrafish
- Zebrafish Proteins/metabolism
- PubMed
- 27015586 Full text @ Ann N Y Acad Sci
Citation
Kanz, D., Konantz, M., Alghisi, E., North, T.E., Lengerke, C. (2016) Endothelial-to-hematopoietic transition: Notch-ing vessels into blood. Annals of the New York Academy of Sciences. 1370(1):97-108.
Abstract
During development, hematopoietic stem cells (HSCs) are formed in a temporally and spatially restricted manner, arising from specialized endothelial cells (ECs) in the ventral wall of the dorsal aorta within the evolutionary conserved aorta-gonad-mesonephros region. Our understanding of the processes regulating the birth of HSCs from ECs has been recently advanced by comprehensive molecular analyses of developing murine hematopoietic cell populations complemented by studies in the zebrafish model, with the latter offering unique advantages for genetic studies and direct in vivo visualization of HSC emergence. Here, we provide a concise review of the current knowledge and recent advances regarding the cellular origin and molecular regulation of HSC development, with particular focus on the process of endothelial-to-hematopoietic transition and its primary regulator, the Notch signaling pathway.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping