PUBLICATION

Vestibular blueprint in early vertebrates

Authors
Straka, H., Baker, R.
ID
ZDB-PUB-160324-18
Date
2013
Source
Frontiers in neural circuits   7: 182 (Review)
Registered Authors
Baker, Robert, Straka, Hans
Keywords
extraocular motoneurons, eye movements, goldfish, hindbrain segment, otolith, semicircular canal, vestibuloocular, vestibulospinal
MeSH Terms
  • Animals
  • Biological Evolution
  • Neural Pathways/physiology
  • Neurons/physiology*
  • Vertebrates
  • Vestibular Nerve/physiology*
  • Vestibular Nuclei/physiology*
  • Vestibule, Labyrinth/physiology*
PubMed
24312016 Full text @ Front. Neural Circuits
Abstract
Central vestibular neurons form identifiable subgroups within the boundaries of classically outlined octavolateral nuclei in primitive vertebrates that are distinct from those processing lateral line, electrosensory, and auditory signals. Each vestibular subgroup exhibits a particular morpho-physiological property that receives origin-specific sensory inputs from semicircular canal and otolith organs. Behaviorally characterized phenotypes send discrete axonal projections to extraocular, spinal, and cerebellar targets including other ipsi- and contralateral vestibular nuclei. The anatomical locations of vestibuloocular and vestibulospinal neurons correlate with genetically defined hindbrain compartments that are well conserved throughout vertebrate evolution though some variability exists in fossil and extant vertebrate species. The different vestibular subgroups exhibit a robust sensorimotor signal processing complemented with a high degree of vestibular and visual adaptive plasticity.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping