Two phases of aging separated by the Smurf transition as a public path to death
- Dambroise, E., Monnier, L., Ruisheng, L., Aguilaniu, H., Joly, J.S., Tricoire, H., Rera, M.
- Scientific Reports 6: 23523 (Journal)
- Registered Authors
- Joly, Jean-Stephane
- Evolution, Physiology
- MeSH Terms
- Biological Evolution*
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins/metabolism
- Conserved Sequence
- Drosophila Proteins/metabolism
- Gene Expression Regulation
- Ubiquitin-Protein Ligases/metabolism*
- Zebrafish Proteins/metabolism
- 27002861 Full text @ Sci. Rep.
Dambroise, E., Monnier, L., Ruisheng, L., Aguilaniu, H., Joly, J.S., Tricoire, H., Rera, M. (2016) Two phases of aging separated by the Smurf transition as a public path to death. Scientific Reports. 6:23523.
Aging's most obvious characteristic is the time dependent increase of an individual's probability to die. This lifelong process is accompanied by a large number of molecular and physiological changes. Although numerous genes involved in aging have been identified in the past decades its leading factors have yet to be determined. To identify the very processes driving aging we have developed in the past years an assay to identify physiologically old individuals in a synchronized population of Drosophila melanogaster. Those individuals show an age-dependent increase of intestinal permeability followed by a high risk of death. Here we show that this physiological marker of aging is conserved in 3 invertebrate species Drosophila mojavensis, Drosophila virilis, Caenorhabditis elegans as well as in 1 vertebrate species Danio rerio. Our findings suggest that intestinal barrier dysfunction may be an important event in the aging process conserved across a broad range of species, thus raising the possibility that it may also be the case in Homo sapiens.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes