PUBLICATION
Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish
- Authors
- Collins, M.M., Stainier, D.Y.
- ID
- ZDB-PUB-160313-2
- Date
- 2016
- Source
- Current topics in developmental biology 117: 417-433 (Chapter)
- Registered Authors
- Stainier, Didier
- Keywords
- Cardiac function, Fluid flow, Heart, Hemodynamic forces, Morphogenesis, Organogenesis, Shear stress, Trabeculation, Valve, Zebrafish
- MeSH Terms
-
- Animals
- Heart/embryology
- Heart/growth & development*
- Morphogenesis/physiology*
- Myocytes, Cardiac/cytology*
- Zebrafish/embryology*
- PubMed
- 26969993 Full text @ Curr. Top. Dev. Biol.
Citation
Collins, M.M., Stainier, D.Y. (2016) Organ Function as a Modulator of Organ Formation: Lessons from Zebrafish. Current topics in developmental biology. 117:417-433.
Abstract
Organogenesis requires an intricate balance between cell differentiation and tissue growth to generate a complex and fully functional organ. However, organogenesis is not solely driven by genetic inputs, as the development of several organ systems requires their own functionality. This theme is particularly evident in the developing heart as progression of cardiac development is accompanied by increased and altered hemodynamic forces. In the absence or disruption of these forces, heart development is abnormal, suggesting that the heart must sense these changes and respond appropriately. Here, we discuss concepts of how embryonic heart function contributes to heart development using lessons learned mostly from studies in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping