PUBLICATION
Biphasic and triphasic dose responses in zebrafish embryos to low-dose 150 kV X-rays with different levels of hardness
- Authors
- Kong, E.Y., Cheng, S.H., Yu, K.N.
- ID
- ZDB-PUB-160310-18
- Date
- 2016
- Source
- Journal of radiation research 57(4): 363-9 (Journal)
- Registered Authors
- Cheng, Shuk Han
- Keywords
- none
- MeSH Terms
-
- Animals
- Apoptosis/radiation effects
- Dose-Response Relationship, Radiation
- Embryo, Nonmammalian/radiation effects*
- Female
- Hardness
- Male
- X-Rays
- Zebrafish/embryology*
- PubMed
- 26951078 Full text @ J. Radiat. Res.
Citation
Kong, E.Y., Cheng, S.H., Yu, K.N. (2016) Biphasic and triphasic dose responses in zebrafish embryos to low-dose 150 kV X-rays with different levels of hardness. Journal of radiation research. 57(4):363-9.
Abstract
The in vivo low-dose responses of zebrafish (Danio rerio) embryos to 150 kV X-rays with different levels of hardness were examined through the number of apoptotic events revealed at 24 h post fertilization by vital dye acridine orange staining. Our results suggested that a triphasic dose response was likely a common phenomenon in living organisms irradiated by X-rays, which comprised an ultra-low-dose inhibition, low-dose stimulation and high-dose inhibition. Our results also suggested that the hormetic zone (or the stimulation zone) was shifted towards lower doses with application of filters. The non-detection of a triphasic dose response in previous experiments could likely be attributed to the use of hard X-rays, which shifted the hormetic zone into an unmonitored ultra-low-dose region. In such cases where the subhormetic zone was missed, a biphasic dose response would be reported instead.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping