PUBLICATION

The function of the Egr1 transcription factor in cartilage formation and adaptation to microgravity in zebrafish, Danio rerio

Authors: Muller, M., Dalcq, J., Aceto, J., Larbuisson, A., Pasque, V., Nourizadeh-Lilladadi, R., Alestrom, P., Martial, J. A.
ID: ZDB-PUB-160219-17
Date: 2010
Source: Zeitschrift fur angewandte Ichthyologie = Journal of applied ichthyology 26(2): 239-244 (Journal)
Registered Authors: Martial, Joseph A., Muller, Marc
Keywords: none
MeSH Terms: none
PubMed: none Full text @ Zeitschrift Angew. Ichthyol. (J. Appl. Ichtyol.)

Abstract

Osteoporosis is one of the major concerns for an ageing human population and for passengers on long-term space flights. Teleosts represent a potentially interesting alternative for studying bone physiology. In zebrafish (Danio rerio), the cartilaginous elements that form the pharyngeal arches derive from cranial neural crest cells, whose proper patterning and morphogenesis require reciprocal interactions with other tissue types such as pharyngeal endoderm, ectoderm and mesoderm. We show how the zebrafish can be used to study the function of signal transduction pathways, such as the Fgf pathway, or that of particular genes, such as the zinc finger transcription factor Egr1, in pharyngeal skeleton formation and maintenance. We investigate the changes caused by microgravity and chemical treatments on zebrafish. We analyze early gene expression modification using whole genome microarray experiments and the long-term consequences by staining bone structures.

Genes / Markers

Figures

Expression

Phenotype

Mutations / Transgenics

Human Disease / Model

Sequence Targeting Reagents

Fish

Antibodies

Orthology

Engineered Foreign Genes

Mapping

Muller et al., 2010 ZDB-PUB-160219-17

The function of the Egr1 transcription factor in cartilage formation and adaptation to microgravity in zebrafish, Danio rerio

Muller et al., 2010

ZDB-PUB-160219-17