PUBLICATION
Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light
- Authors
- Li, L., Sahi, S.K., Peng, M., Lee, E.B., Ma, L., Wojtowicz, J.L., Malin, J.H., Chen, W.
- ID
- ZDB-PUB-160211-14
- Date
- 2016
- Source
- Scientific Reports 6: 20821 (Journal)
- Registered Authors
- Li, Lei
- Keywords
- Biotechnology, Neuroscience
- MeSH Terms
-
- Animals
- Disease Models, Animal
- Light*
- Nanoparticles/radiation effects*
- Optical Devices*
- Photoreceptor Cells/physiology*
- Photoreceptor Cells/radiation effects*
- Retinal Degeneration
- Ultraviolet Rays*
- Zebrafish
- PubMed
- 26860393 Full text @ Sci. Rep.
Citation
Li, L., Sahi, S.K., Peng, M., Lee, E.B., Ma, L., Wojtowicz, J.L., Malin, J.H., Chen, W. (2016) Luminescence- and nanoparticle-mediated increase of light absorption by photoreceptor cells: Converting UV light to visible light. Scientific Reports. 6:20821.
Abstract
We developed new optic devices - singly-doped luminescence glasses and nanoparticle-coated lenses that convert UV light to visible light - for improvement of visual system functions. Tb(3+) or Eu(3+) singly-doped borate glasses or CdS-quantum dot (CdS-QD) coated lenses efficiently convert UV light to 542 nm or 613 nm wavelength narrow-band green or red light, or wide-spectrum white light, and thereby provide extra visible light to the eye. In zebrafish (wild-type larvae and adult control animals, retinal degeneration mutants, and light-induced photoreceptor cell degeneration models), the use of Tb(3+) or Eu(3+) doped luminescence glass or CdS-QD coated glass lenses provide additional visible light to the rod and cone photoreceptor cells, and thereby improve the visual system functions. The data provide proof-of-concept for the future development of optic devices for improvement of visual system functions in patients who suffer from photoreceptor cell degeneration or related retinal diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping