ZFIN ID: ZDB-PUB-160205-1
Leveraging large-scale behavioral profiling in zebrafish to explore neuroactive polypharmacology
McCarroll, M.N., Gendelev, L., Keiser, M.J., Kokel, D.
Date: 2016
Source: ACS Chemical Biology   11(4): 842-9 (Review)
Registered Authors: McCarroll, Matthew N.
Keywords: none
MeSH Terms:
  • Animals
  • Behavior, Animal/drug effects*
  • Polypharmacy*
  • Zebrafish/physiology*
PubMed: 26845413 Full text @ ACS Chem. Biol.
Many psychiatric drugs modulate the nervous system through multi-target mechanisms. However, systematic identification of multi-target compounds has been difficult to achieve using traditional in vitro screening assays. New approaches to phenotypic profiling in zebrafish can help researchers identify novel compounds with complex polypharmacology. For example, large-scale behavior-based chemical screens can rapidly identify large numbers of structurally diverse and phenotype-related compounds. Once these compounds have been identified, a systems-level analysis of their structures may help to identify statistically enriched target pathways. Together, systematic behavioral profiling and multi-target predictions may help researchers identify new behavior-modifying pathways and CNS therapeutics.