PUBLICATION
The smell of “anxiety”: Behavioral modulation by experimental anosmia in zebrafish
- Authors
- Abreu, M.S., Giacomini, A.C., Kalueff, A.V., Barcellos, L.J.
- ID
- ZDB-PUB-160129-4
- Date
- 2016
- Source
- Physiology & behavior 157: 67-71 (Journal)
- Registered Authors
- Kalueff, Allan V.
- Keywords
- Fluoxetine, Food odor, Novel tank, Olfactory sense, Stress
- MeSH Terms
-
- Analysis of Variance
- Anesthetics, Local/toxicity
- Animals
- Antidepressive Agents, Second-Generation/therapeutic use
- Anxiety/drug therapy
- Anxiety/etiology*
- Disease Models, Animal
- Female
- Fluoxetine/therapeutic use
- Hydrocortisone/metabolism
- Lidocaine/toxicity
- Locomotion/drug effects
- Locomotion/physiology
- Male
- Odorants
- Olfaction Disorders/chemically induced
- Olfaction Disorders/complications*
- Statistics, Nonparametric
- Zebrafish
- PubMed
- 26821184 Full text @ Physiol. Behav.
Citation
Abreu, M.S., Giacomini, A.C., Kalueff, A.V., Barcellos, L.J. (2016) The smell of “anxiety”: Behavioral modulation by experimental anosmia in zebrafish. Physiology & behavior. 157:67-71.
Abstract
Olfaction is strongly involved in the regulation of fish behavior, including reproductive, defensive, social and migration behaviors. In fish, anosmia (the lack of olfaction) can be induced experimentally, impairing their ability to respond to various olfactory stimuli. Here, we examine the effects of experimental lidocaine-induced anosmia on anxiety-like behavior in adult zebrafish (Danio rerio). We show that experimentally-induced anosmia reduces anxiolytic-like behavioral effects of fluoxetine and seems to interact with anxiogenic effect of stress. These findings provide first experimental evidence that temporary anosmia modulates anxiety-like behaviors in adult zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping