PUBLICATION
A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors
- Authors
- Wang, Y., Wu, X., Cheng, Y., Zhao, X.
- ID
- ZDB-PUB-160127-2
- Date
- 2016
- Source
- Chemical communications (Cambridge, England) 52(17): 3478-81 (Journal)
- Registered Authors
- Wang, Yi
- Keywords
- none
- MeSH Terms
-
- 3T3-L1 Cells
- Animals
- Dipeptidyl Peptidase 4/chemistry*
- Dipeptidyl-Peptidase IV Inhibitors/chemistry*
- Fluorescent Dyes/chemistry*
- In Vitro Techniques
- Mice
- Microscopy, Fluorescence
- Zebrafish
- PubMed
- 26812581 Full text @ Chem. Commun. (Camb.)
Citation
Wang, Y., Wu, X., Cheng, Y., Zhao, X. (2016) A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors. Chemical communications (Cambridge, England). 52(17):3478-81.
Abstract
A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel approach for the discovery of anti-diabetes drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping