|ZFIN ID: ZDB-PUB-160115-6|
Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
Yan, D., Ni, L.K., Chen, H.L., Chen, L.C., Chen, Y.H., Cheng, C.C.
|Source:||Bioorganic & medicinal chemistry letters 26(3): 774-7 (Journal)|
|Registered Authors:||Chen, Yau-Hung|
|Keywords:||Drug delivery, Liposome, Norcantharidin, Resveratrol, Tadpole structure|
|PubMed:||26764188 Full text @ Bioorg. Med. Chem. Lett.|
Yan, D., Ni, L.K., Chen, H.L., Chen, L.C., Chen, Y.H., Cheng, C.C. (2016) Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo. Bioorganic & medicinal chemistry letters. 26(3):774-7.
ABSTRACTDirect coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol-norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
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