ZFIN ID: ZDB-PUB-160115-6
Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
Yan, D., Ni, L.K., Chen, H.L., Chen, L.C., Chen, Y.H., Cheng, C.C.
Date: 2016
Source: Bioorganic & medicinal chemistry letters   26(3): 774-7 (Journal)
Registered Authors: Chen, Yau-Hung
Keywords: Drug delivery, Liposome, Norcantharidin, Resveratrol, Tadpole structure
MeSH Terms:
  • Animals
  • Bridged Bicyclo Compounds, Heterocyclic/chemistry*
  • Bridged Bicyclo Compounds, Heterocyclic/toxicity
  • Drug Carriers/chemistry
  • Embryo, Nonmammalian/drug effects
  • Hydrophobic and Hydrophilic Interactions
  • Liposomes/chemistry
  • Medicine, Chinese Traditional
  • Nanoparticles/chemistry*
  • Particle Size
  • Stilbenes/chemistry*
  • Stilbenes/toxicity
  • Zebrafish/growth & development
PubMed: 26764188 Full text @ Bioorg. Med. Chem. Lett.
ABSTRACT
Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol-norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
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