PUBLICATION
Chiral bioaccumulation behavior of tebuconazole in the zebrafish (Danio rerio)
- Authors
- Liu, N., Dong, F., Xu, J., Liu, X., Zheng, Y.
- ID
- ZDB-PUB-160102-1
- Date
- 2016
- Source
- Ecotoxicology and environmental safety 126: 78-84 (Journal)
- Registered Authors
- Xu, Jun
- Keywords
- Bioaccumulation, Enantioselectivity, Tebuconazole, Zebrafish
- MeSH Terms
-
- Animals
- Fungicides, Industrial/chemistry
- Fungicides, Industrial/pharmacokinetics*
- Stereoisomerism
- Triazoles/chemistry
- Triazoles/pharmacokinetics*
- Water Pollutants, Chemical/chemistry
- Water Pollutants, Chemical/pharmacokinetics*
- Zebrafish/metabolism*
- PubMed
- 26722978 Full text @ Ecotoxicol. Environ. Saf.
Citation
Liu, N., Dong, F., Xu, J., Liu, X., Zheng, Y. (2016) Chiral bioaccumulation behavior of tebuconazole in the zebrafish (Danio rerio). Ecotoxicology and environmental safety. 126:78-84.
Abstract
Tebuconazole is an effective chiral fungicide, and previous studies have demonstrated that tebuconazole enantiomers exhibit enantioselective toxicity to non-target aquatic organisms. Thus, the aim of the present study was to investigate the chiral bioaccumulation behavior of tebuconazole in zebrafish (Danio rerio). Two exposure concentrations (0.107 and 1.07mg/L) of tebuconazole were used. The uptake experiments lasted for 8 days, and subsequently, the zebrafish were transferred to another clean tank containing water without tebuconazole for depuration experiments (up to 14 days). A significant trend in enantioselective bioaccumulation was observed in these zebrafish with the preferential accumulation of (-)-R-tebuconazole at two dose levels. The results of the depuration experiments indicated that the degradation of (-)-R-tebuconazole in zebrafish was slower than that of (+)-S-tebuconazole. The BCFk values for (+)-S-tebuconazole and (-)-R-tebuconazole in a low dose of this chemical were 11.22 and 16.25, respectively, while at a high dose, these values were 9.79 and 10.31, respectively. The enantiomer fraction of tebuconazole in zebrafish and water ranged from 0.31-0.49. Hence, future research should focus on the fate of tebuconazole in the aquatic environment at the enantiomer levels.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping