PUBLICATION

Genome-wide epigenetic cross-talk between DNA methylation and H3K27me3 in zebrafish embryos

Authors
de la Calle Mustienes, E., Gómez-Skarmeta, J.L., Bogdanović, O.
ID
ZDB-PUB-151224-3
Date
2015
Source
Genomics Data   6: 7-9 (Journal)
Registered Authors
Gómez-Skarmeta, José Luis
Keywords
DNA methylation, Embryogenesis, Polycomb, Zebrafish
Datasets
GEO:GSE70847, GEO:GSE35050
MeSH Terms
none
PubMed
26697317 Full text @ Genom. Data
Abstract
DNA methylation and histone modifications are epigenetic marks implicated in the complex regulation of vertebrate embryogenesis. The cross-talk between DNA methylation and Polycomb-dependent H3K27me3 histone mark has been reported in a number of organisms [1], [2], [3], [4], [5], [6], [7] and both marks are known to be required for proper developmental progression. Here we provide genome-wide DNA methylation (MethylCap-seq) and H3K27me3 (ChIP-seq) maps for three stages (dome, 24 hpf and 48 hpf) of zebrafish (Danio rerio) embryogenesis, as well as all analytical and methodological details associated with the generation of this dataset. We observe a strong antagonism between the two epigenetic marks present in CpG islands and their compatibility throughout the bulk of the genome, as previously reported in mammalian ESC lines (Brinkman et al., 2012). Next generation sequencing data linked to this project have been deposited in the Gene Expression Omnibus (GEO) database under accession numbers GSE35050 and GSE70847.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping