PUBLICATION
Trans-generational transmission of neurobehavioral impairments produced by developmental methylmercury exposure in zebrafish (Danio rerio)
- Authors
- Xu, X., Weber, D., Martin, A., Lone, D.
- ID
- ZDB-PUB-151114-10
- Date
- 2016
- Source
- Neurotoxicology and teratology 53: 19-23 (Journal)
- Registered Authors
- Weber, Dan
- Keywords
- Active avoidance conditioning, Learning, Methylmercury, Trans-generational, Zebrafish
- MeSH Terms
-
- Analysis of Variance
- Animals
- Avoidance Learning/drug effects*
- Dose-Response Relationship, Drug
- Embryo, Nonmammalian/drug effects*
- Larva
- Learning Disabilities/chemically induced*
- Learning Disabilities/genetics*
- Methylmercury Compounds/toxicity*
- Zebrafish
- PubMed
- 26561945 Full text @ Neurotoxicol. Teratol.
Citation
Xu, X., Weber, D., Martin, A., Lone, D. (2016) Trans-generational transmission of neurobehavioral impairments produced by developmental methylmercury exposure in zebrafish (Danio rerio). Neurotoxicology and teratology. 53:19-23.
Abstract
Our previous study showed that embryonic exposures to methylmercury (MeHg) produced learning impairments in adult zebrafish. The present study investigated the persistency of learning impairments in the second (F2) and third (F3) generations of zebrafish developmentally exposed to MeHg as embryos using active avoidance conditioning as the behavioral paradigm. The results showed that the control zebrafish learned avoidance responses during training and significantly increased avoidance responses during testing. The F2 generation of zebrafish developmentally exposed to MeHg as embryos displayed no significant changes in avoidance responses from training to testing, showing persistent learning impairments, while the F3 generation of zebrafish developmentally exposed as embryos to only the higher concentration of MeHg showed persistent learning impairments. Results of the present study showed that learning impairments produced by embryonic MeHg exposure persisted for at least three generations, demonstrating trans-generational effects of embryonic exposure to MeHg.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping