ZFIN ID: ZDB-PUB-151028-2
Alkaloids with Cardiovascular Effects from the Marine-Derived Fungus Penicillium expansum Y32
Fan, Y.Q., Li, P.H., Chao, Y.X., Chen, H., Du, N., He, Q.X., Liu, K.C.
Date: 2015
Source: Marine drugs   13: 6489-6504 (Journal)
Registered Authors: Chen, Hao
Keywords: Penicillium expansum, alkaloids, cardiovascular effects, marine-derived fungus, secondary metabolites
MeSH Terms:
  • Alkaloids/chemistry
  • Alkaloids/isolation & purification
  • Alkaloids/pharmacology*
  • Animals
  • Astemizole/pharmacology
  • Bradycardia/drug therapy*
  • Cardiovascular Agents/chemistry
  • Cardiovascular Agents/isolation & purification
  • Cardiovascular Agents/pharmacology*
  • Circular Dichroism
  • Heart Rate/drug effects
  • Neovascularization, Physiologic/drug effects
  • Penicillium/metabolism*
  • Secondary Metabolism
  • Zebrafish
PubMed: 26506361 Full text @ Mar. Drugs
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ABSTRACT
Three new alkaloids (1, 4 and 8), together with nine known analogues (2, 3, 5-7, and 9-12), were isolated from the marine-derived fungus Penicillium expansum Y32. Their structures including the absolute configurations were elucidated by spectroscopic and Mosher's and Marfey's methods, along with quantum electronic circular dichroism (ECD) calculations. Each of the compounds was evaluated for cardiovascular effects in a live zebrafish model. All of the compounds showed a significant mitigative effect on bradycardia caused by astemizole (ASM) in the heart rate experiments. Compounds 4-6 and 8-12 exhibited potent vasculogenetic activity in vasculogenesis experiments. This is the first study to report that these types of compounds show cardiovascular effects in zebrafish. The results suggest that these compounds could be promising candidates for cardiovascular disease lead compounds.
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