PUBLICATION
[Potential of the zebrafish model to study congenital muscular dystrophies]
- Authors
- Ryckebüsch, L.
- ID
- ZDB-PUB-151021-14
- Date
- 2015
- Source
- Medecine sciences : M/S 31: 912-9 (Journal)
- Registered Authors
- Ryckebüsch, Lucile
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Collagen/genetics
- Disease Models, Animal*
- Embryo, Nonmammalian
- Humans
- Laminin/genetics
- Mice
- Muscle, Skeletal/pathology
- Muscular Dystrophies/congenital*
- Muscular Dystrophies/genetics
- Muscular Dystrophies/pathology*
- Protein Isoforms
- Zebrafish*/embryology
- Zebrafish*/genetics
- PubMed
- 26481031 Full text @ Med. Sci. (Paris)
Citation
Ryckebüsch, L. (2015) [Potential of the zebrafish model to study congenital muscular dystrophies]. Medecine sciences : M/S. 31:912-9.
Abstract
In order to better understand the complexity of congenital muscular dystrophies (CMD) and develop new strategies to cure them, it is important to establish new disease models. Due to its numerous helpful attributes, the zebrafish has recently become a very powerful animal model for the study of CMD. For some CMD, this vertebrate model is phenotypically closer to human pathology than the murine model. Over the last few years, researchers have developed innovative techniques to screen rapidly and on a large scale for muscle defects in zebrafish. Furthermore, new genome editing techniques in zebrafish make possible the identification of new disease models. In this review, the major attributes of zebrafish for CMD studies are discussed and the principal models of CMD in zebrafish are highlighted.
Errata / Notes
[Article in French]
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping