PUBLICATION
Regeneration versus scarring in vertebrate appendages and heart
- Authors
- Jaźwińska, A., Sallin, P.
- ID
- ZDB-PUB-150929-5
- Date
- 2016
- Source
- The Journal of pathology 238(2): 233-46 (Review)
- Registered Authors
- Jazwinska, Anna
- Keywords
- Fin, blastema, cardiomyocyte, cellular specialization, cytodifferentiation, epimorphosis, fibroblast, limb, urodele, wound epidermis, zebrafish
- MeSH Terms
-
- Animal Fins/physiology
- Animal Structures/physiology*
- Animals
- Cell Differentiation/physiology
- Cell Division
- Cell Movement/physiology
- Cicatrix/physiopathology
- Heart/physiology*
- Humans
- Mammals/physiology
- Models, Animal*
- Myocytes, Cardiac/physiology
- Regeneration/physiology*
- Urodela/physiology*
- Zebrafish/physiology*
- PubMed
- 26414617 Full text @ J. Pathol.
Citation
Jaźwińska, A., Sallin, P. (2016) Regeneration versus scarring in vertebrate appendages and heart. The Journal of pathology. 238(2):233-46.
Abstract
Injuries to human complex organs, such as the limbs and the heart, result in pathologic conditions, for which we often lack adequate treatments. While modern regenerative approaches are based on the transplantation of stem cell-derived cells, natural regeneration in lower vertebrates, such as zebrafish and newts, relies predominantly on the intrinsic plasticity of mature tissues. This property involves local activation of the remaining material at the site of injury to promote cell division, cell migration and complete reproduction of the missing structure. It remains an unresolved question why adult mammals are not equally competent to reactivate morphogenetic programs. Although organ regeneration depends strongly on proliferative properties of cells in the injured tissue, it is apparent that various organismic factors, such as innervation, vascularization, hormones, metabolism and the immune system, can affect this process. Here, we focus on a correlation between the regenerative capacity and cellular specialization in the context of functional demands, as illustrated by appendages and heart in diverse vertebrates. Elucidation of the differences between homologous regenerative and non-regenerative tissues from various animal models is essential for understanding the applicability of lessons learned from the study of regenerative biology to clinical strategies for treatment of human injured organs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping