PUBLICATION

Teratogenic, bioenergetic, and behavioral effects of exposure to total particulate matter on early development of zebrafish (Danio rerio) are not mimicked by nicotine

Authors
Massarsky, A., Jayasundara, N., Bailey, J.M., Oliveri, A.N., Levin, E.D., Prasad, G.L., Di Giulio, R.T.
ID
ZDB-PUB-150924-12
Date
2015
Source
Neurotoxicology and teratology   51: 77-88 (Journal)
Registered Authors
Di Giulio, Richard T.
Keywords
Behavior, Cigarette smoke, Early development, Total particulate matter, Toxicity, Zebrafish
MeSH Terms
  • Analysis of Variance
  • Animals
  • Behavior, Animal/drug effects*
  • Cytochrome P-450 CYP1A1/metabolism
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Embryo, Nonmammalian/drug effects
  • Energy Metabolism/drug effects*
  • Hemoglobins/metabolism
  • Neovascularization, Physiologic/drug effects
  • Nicotine/toxicity*
  • Nicotinic Agonists/toxicity*
  • Oxidative Stress/drug effects
  • Particulate Matter/toxicity*
  • Teratogens
  • Xenobiotics/metabolism
  • Zebrafish
PubMed
26391568 Full text @ Neurotoxicol. Teratol.
Abstract
Cigarette smoke has been associated with a number of pathologies; however, the mechanisms leading to developmental effects are yet to be fully understood. The zebrafish embryo is regarded as a 'bridge model'; however, not many studies examined its applicability to cigarette smoke toxicity. This study examined the effects of total particulate matter (TPM) from 3R4F reference cigarettes on the early development of zebrafish (Danio rerio). Zebrafish embryos were exposed to two concentrations of TPM (0.4 and 1.4μg/mL equi-nicotine units) or nicotine at equivalent doses. The exposures began at 2h post-fertilization (hpf) and lasted until 96hpf. Several physiological parameters were assessed during or after the exposure. We show that TPM increased mortality, delayed hatching, and increased the incidence of deformities in zebrafish. TPM exposure also increased the incidence of hemorrhage and disrupted the angiogenesis of the major vessels in the brain. Moreover, TPM exposure reduced the larval body length, decreased the heart rate, and reduced the metabolic rate. Biomarkers of xenobiotic metabolism and oxidative stress were also affected. TPM-exposed zebrafish also differed behaviorally: at 24h post-fertilization (hpf) the embryos had a higher frequency of spontaneous contractions and at 144hpf the larvae displayed swimming hyperactivity. This study demonstrates that TPM disrupts several aspects of early development in zebrafish. The effects reported for TPM were not attributable to nicotine, since embryos treated with nicotine alone did not differ significantly from the control group. Collectively, our work illustrates the utility of zebrafish as an alternative model to evaluate the toxic effects of cigarette smoke constituents.
Genes / Markers
Figures
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Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping