PUBLICATION
Zebrafish as tools for drug discovery
- Authors
- MacRae, C.A., Peterson, R.T.
- ID
- ZDB-PUB-150912-2
- Date
- 2015
- Source
- Nature reviews. Drug discovery 14(10): 721-31 (Review)
- Registered Authors
- MacRae, Calum A., Peterson, Randall
- Keywords
- Drug safety, Phenotypic screening, Zebrafish
- MeSH Terms
-
- Animals
- Drug Discovery*
- Drug Evaluation, Preclinical
- Embryo, Nonmammalian/drug effects
- Humans
- Models, Animal
- Pyrazoles/pharmacology
- Pyrimidines/pharmacology
- Zebrafish*/embryology
- Zebrafish*/physiology
- PubMed
- 26361349 Full text @ Nat. Rev. Drug Discov.
Citation
MacRae, C.A., Peterson, R.T. (2015) Zebrafish as tools for drug discovery. Nature reviews. Drug discovery. 14(10):721-31.
Abstract
The zebrafish has become a prominent vertebrate model for disease and has already contributed to several examples of successful phenotype-based drug discovery. For the zebrafish to become useful in drug development more broadly, key hurdles must be overcome, including a more comprehensive elucidation of the similarities and differences between human and zebrafish biology. Recent studies have begun to establish the capabilities and limitations of zebrafish for disease modelling, drug screening, target identification, pharmacology, and toxicology. As our understanding increases and as the technologies for manipulating zebrafish improve, it is hoped that the zebrafish will have a key role in accelerating the emergence of precision medicine.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping