PUBLICATION
Hematopoiesis: An Evolving Paradigm for Stem Cell Biology
- Authors
- Orkin, S.H., Zon, L.I.
- ID
- ZDB-PUB-150817-3
- Date
- 2008
- Source
- Cell 132: 631-644 (Review)
- Registered Authors
- Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Lineage
- Cell Movement
- Hematopoiesis*
- Hematopoietic Stem Cells/cytology
- Humans
- Transcription Factors/metabolism
- PubMed
- 18295580 Full text @ Cell
Citation
Orkin, S.H., Zon, L.I. (2008) Hematopoiesis: An Evolving Paradigm for Stem Cell Biology. Cell. 132:631-644.
Abstract
Establishment and maintenance of the blood system relies on self-renewing hematopoietic stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult mammals. This Review describes the developmental origins of HSCs and the molecular mechanisms that regulate lineage-specific differentiation. Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of cellular interactions in development and tissue homeostasis, lineage programming and reprogramming by transcription factors, and stage- and age-specific differences in cellular phenotypes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping