PUBLICATION
Do not scratch that mole!
- Authors
- Jelcic, M., Niethammer, P.
- ID
- ZDB-PUB-150809-2
- Date
- 2015
- Source
- Trends in immunology 36(9): 503-4 (Other)
- Registered Authors
- Niethammer, Philipp
- Keywords
- none
- MeSH Terms
-
- Animals
- Humans
- Melanoma/immunology*
- Neoplasms, Experimental/immunology*
- Precancerous Conditions/immunology*
- Wounds and Injuries/immunology*
- Zebrafish/immunology*
- PubMed
- 26254146 Full text @ Trends Immunol.
Citation
Jelcic, M., Niethammer, P. (2015) Do not scratch that mole!. Trends in immunology. 36(9):503-4.
Abstract
Nevi harbor some of the same oncogene mutations that also drive malign melanoma. Further tumor promoting events are required to unleash their carcinogenic potential. Using zebrafish whose melanocytes overexpress an HRAS-oncogene, a new study reports that injury induces melanoma, possibly through recruitment of neutrophils that trigger proliferation of preneoplastic melanocytes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping