PUBLICATION
Optogenetic neuromodulation: New tools for monitoring and breaking neural circuits
- Authors
- Knafo, S., Wyart, C.
- ID
- ZDB-PUB-150707-7
- Date
- 2015
- Source
- Annals of physical and rehabilitation medicine 58(4): 259-64 (Other)
- Registered Authors
- Wyart, Claire
- Keywords
- Neuromodulation, Optogenetics, Sensorimotor integration, Zebrafish
- MeSH Terms
-
- Animals
- Genes, Reporter
- Humans
- Monitoring, Physiologic/methods*
- Neural Conduction/physiology*
- Neurons/physiology*
- Optogenetics*
- Spinal Cord/cytology
- Spinal Cord Injuries/physiopathology
- Spinal Cord Injuries/rehabilitation
- Zebrafish
- PubMed
- 26143950 Full text @ Ann Phys Rehabil Med
Citation
Knafo, S., Wyart, C. (2015) Optogenetic neuromodulation: New tools for monitoring and breaking neural circuits. Annals of physical and rehabilitation medicine. 58(4):259-64.
Abstract
Optogenetics is the combination of optical tools to monitor (i.e. "reporters") or interfere (i.e. "actuators") with neural activity, and genetic techniques to restrain the expression of these reporters and actuators in the neuronal populations of interest. Such combination of optical and genetic tools, together with the emergence of new animal models such as the zebrafish larva, has proven extremely valuable is dissecting neural circuits. Optogenetics provide a new framework to address issues that are fundamentally dynamic processes, such as sensorimotor integration in the vertebrate spinal cord. By shifting from spatially targeted electrical stimulation to genetically targeted optical stimulation, optogenetic also opens new avenues for innovative neurorehabilitative strategies, in particular after spinal cord injury.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping