PUBLICATION
Migratory neuronal precursor populations arising from the zebrafish cerebellar rhombic lip
- Authors
- Volkmann, K.
- ID
- ZDB-PUB-150706-12
- Date
- 2010
- Source
- Thesis : 103 (Thesis)
- Registered Authors
- Volkmann, Katrin
- Keywords
- zebrafish, imaging, neuronal migration, cerebellar development
- MeSH Terms
- none
- PubMed
- none
Citation
Volkmann, K. (2010) Migratory neuronal precursor populations arising from the zebrafish cerebellar rhombic lip. Thesis. :103.
Abstract
This study describes the identification and characterization of migratory neuronal precursor populations arising from the rhombic lip in the developing cerebellum of the model organism zebrafish, namely the precursors of the tegmental hindbrain nuclei neurons of rhombomere 1 and the cerebellar granule cells. Their migratory behavior is analyzed in detail as is their differentiation, the expression of adhesion and guidance factors and their final integration into neuronal circuitries. This work demonstrates the high grade of conservation of the cerebellar rhombic lip as a proliferation zone that produces different neuronal cell types over time among vertebrate species. Moreover it reveals that the cerebellar rhombic lip is spatially subdivided to simultaneously produce granule cells of different connectivity and function.
Errata / Notes
Mùˆnchen, Techn. Univ., Diss.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping