PUBLICATION
Addressing the Genetics of Human Mental Health Disorders in Model Organisms
- Authors
- McCammon, J.M., Sive, H.
- ID
- ZDB-PUB-150524-3
- Date
- 2015
- Source
- Annual review of genomics and human genetics 16: 173-97 (Review)
- Registered Authors
- McCammon, Jasmine, Sive, Hazel
- Keywords
- psychiatric disorders, autism, schizophrenia, zebrafish
- MeSH Terms
-
- Animals
- Aplysia/genetics
- Behavior, Animal/physiology
- Caenorhabditis elegans/genetics
- Cells, Cultured
- Disease Models, Animal*
- Drosophila melanogaster/genetics
- Drug Discovery
- Drug Evaluation, Preclinical/methods*
- Gene Expression Regulation
- Humans
- Mental Disorders/drug therapy
- Mental Disorders/genetics*
- Mental Disorders/pathology*
- Mice
- Neurons/pathology
- Pluripotent Stem Cells/pathology
- Pluripotent Stem Cells/physiology
- Xenopus laevis/genetics
- Zebrafish
- PubMed
- 26002061 Full text @ Annu. Rev. Genomics Hum. Genet.
Citation
McCammon, J.M., Sive, H. (2015) Addressing the Genetics of Human Mental Health Disorders in Model Organisms. Annual review of genomics and human genetics. 16:173-97.
Abstract
Mental health disorders are notoriously difficult to diagnose and treat for a variety of reasons, including genetic heterogeneity, comorbidities, and qualitative diagnostic criteria. Discovery of the molecular pathology underlying these disorders is crucial to the development of quantitative biomarkers and novel therapeutics. In this review, we discuss contributions to the mental health field of different cellular and whole-animal approaches in characterizing psychiatric genetics and molecular pathology. These approaches include mammalian cell and neuronal culture, cerebral organoids, induced pluripotent stem cells, and the whole-animal models of nematodes, flies, mollusks, frogs, mice, and zebrafish, on the last of which we place extra emphasis. Integrative use of these cellular and animal systems in a complementary and informative fashion maximizes the potential contributions to the mental health field as a whole.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping