PUBLICATION
Zebrafish Renal Pathology: Emerging Models of Acute Kidney Injury
- Authors
- McKee, R.A., Wingert, R.A.
- ID
- ZDB-PUB-150515-3
- Date
- 2015
- Source
- Current pathobiology reports 3: 171-181 (Journal)
- Registered Authors
- McKee, Robert, Wingert, Rebecca
- Keywords
- Acute kidney injury, Nephron, Regeneration, Renal progenitor, Renal stem cell, Zebrafish
- MeSH Terms
- none
- PubMed
- 25973344 Full text @ Curr Pathobiol Rep
Citation
McKee, R.A., Wingert, R.A. (2015) Zebrafish Renal Pathology: Emerging Models of Acute Kidney Injury. Current pathobiology reports. 3:171-181.
Abstract
The renal system is vital to maintain homeostasis in the body, where the kidneys contain nephron functional units that remove metabolic waste from the bloodstream, regulate fluids, and balance electrolytes. Severe organ damage from toxins or ischemia that occurs abruptly can cause acute kidney injury (AKI) in which there is a rapid, life-threatening loss of these activities. Humans have a limited but poorly understood ability to regenerate damaged nephrons after AKI. However, researchers studying AKI in vertebrate animal models such as mammals, and more recently the zebrafish, have documented robust regeneration within the nephron blood filter and tubule following injury. Further, zebrafish kidneys contain progenitors that create new nephrons after AKI. Here, we review investigations in zebrafish which have established a series of exciting renal pathology paradigms that complement existing AKI models and can be implemented to discover insights into kidney regeneration and the roles of stem cells.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping