ZFIN ID: ZDB-PUB-150429-5
Ribbon Synapses in Zebrafish Hair Cells
Nicolson, T.
Date: 2015
Source: Hearing Research   330(Pt B): 170-7 (Review)
Registered Authors: Nicolson, Teresa
Keywords: Cav1.3a, Rbc3a, Ribeye, Synj1, Vglut3, hair cell, ribbon synapses, zebrafish
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Auditory Pathways/physiology
  • Calcium Signaling
  • Genotype
  • Hair Cells, Auditory/metabolism
  • Hair Cells, Auditory/physiology*
  • Hearing
  • Mechanotransduction, Cellular
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/metabolism
  • Phenotype
  • Synaptic Transmission*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
PubMed: 25916266 Full text @ Hear. Res.
The basic architecture and functionality of ribbon synapses of mechanosensitive hair cells are well conserved among vertebrates. Forward and reverse genetic methods in zebrafish (Danio rerio) have identified components that are critical for the development and function of ribbon synapses. This review will focus on the findings of these genetic approaches, and discuss some emergent concepts on the role of the ribbon body and calcium in synapse development, and how perturbations in synaptic vesicles lead to a loss of temporal fidelity at ribbon synapses.