PUBLICATION

Pineal-specific agouti protein regulates teleost background adaptation

Authors
Zhang, C., Song, Y., Thompson, D.A., Madonna, M.A., Millhauser, G.L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., Cone, R.D.
ID
ZDB-PUB-150209-1
Date
2010
Source
Proceedings of the National Academy of Sciences of the United States of America   107(47): 20164-71 (Journal)
Registered Authors
Chen, Wenbiao, Cone, Roger, Gamse, Josh, Toro, Sabrina, Varga, Zoltan M., Westerfield, Monte
Keywords
pigmentation, camouflage, zebrafish
MeSH Terms
  • Adaptation, Physiological/genetics*
  • Agouti-Related Protein/metabolism*
  • Animals
  • Gene Expression Regulation/physiology
  • Melanosomes/metabolism
  • Pigmentation/genetics*
  • Pigmentation/physiology
  • Pineal Gland/metabolism*
  • Receptor, Melanocortin, Type 1/antagonists & inhibitors
  • Zebrafish/genetics
  • Zebrafish/metabolism*
PubMed
20980662 Full text @ Proc. Natl. Acad. Sci. USA
Abstract
Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoidance of predation. Background adaptation is known to involve light sensing by the retina and subsequent regulation of melanophore dispersion or contraction in melanocytes, mediated by α-melanocyte-stimulating hormone and melanin-concentrating hormone, respectively. Here, we demonstrate that an agouti gene unique to teleosts, agrp2, is specifically expressed in the pineal and is required for up-regulation of hypothalamic pmch and pmchl mRNA and melanosome contraction in dermal melanocytes in response to a white background. floating head, a mutant with defective pineal development, exhibits defective up-regulation of mch mRNAs by white background, whereas nrc, a blind mutant, exhibits a normal response. These studies identify a role for the pineal in background adaptation in teleosts, a unique physiological function for the agouti family of proteins, and define a neuroendocrine axis by which environmental background regulates pigmentation.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes