PUBLICATION
Recent advances in the study of zebrafish extracellular matrix proteins
- Authors
- Jessen, J.R.
- ID
- ZDB-PUB-150103-4
- Date
- 2015
- Source
- Developmental Biology 401(1): 110-21 (Review)
- Registered Authors
- Jessen, Jason R.
- Keywords
- Collagen, Extracellular matrix, Fibronectin, Laminin, Morphogenesis, Zebrafish
- MeSH Terms
-
- Animals
- Body Patterning/physiology
- Cell Movement/physiology*
- Cell Polarity/physiology*
- Collagen/metabolism
- Extracellular Matrix Proteins/metabolism*
- Fibronectins/metabolism
- Gastrula/embryology
- Heart/embryology*
- Laminin/metabolism
- Morphogenesis/physiology*
- Muscle Contraction/physiology
- Neural Crest/embryology
- Somites/physiology*
- Zebrafish/embryology*
- Zebrafish/metabolism
- PubMed
- 25553981 Full text @ Dev. Biol.
Citation
Jessen, J.R. (2015) Recent advances in the study of zebrafish extracellular matrix proteins. Developmental Biology. 401(1):110-21.
Abstract
The zebrafish extracellular matrix (ECM) is a dynamic and pleomorphic structure consisting of numerous proteins that together regulate a variety of cellular and morphogenetic events beginning as early as gastrulation. The zebrafish genome encodes a similar complement of ECM proteins as found in other vertebrate organisms including glycoproteins, fibrous proteins, proteoglycans, glycosaminoglycans, and interacting or modifying proteins such as integrins and matrix metalloproteinases. As a genetic model system combined with its amenability to high-resolution microscopic imaging, the zebrafish allows interrogation of ECM protein structure and function in both the embryo and adult. Accumulating data have identified important roles for zebrafish ECM proteins in processes as diverse as cell polarity, migration, tissue mechanics, organ laterality, muscle contraction, and regeneration. In this review, I highlight recently published data on these topics that demonstrate how the ECM proteins fibronectin, laminin, and collagen contribute to zebrafish development and adult homeostasis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping