PUBLICATION
Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish
- Authors
- Boyle, D., Boran, H., Atfield, A., Henry, T.B.
- ID
- ZDB-PUB-141230-4
- Date
- 2015
- Source
- Environmental toxicology and chemistry 34(3): 583-8 (Journal)
- Registered Authors
- Henry, Theodore B.
- Keywords
- Acute toxicity, Danio rerio, Engineered nanoparticles, Nanoparticle exposure chamber
- MeSH Terms
-
- Animals
- Environmental Exposure/analysis*
- Larva/drug effects
- Nanoparticles/toxicity*
- Particle Size
- Silver/analysis
- Toxicity Tests/methods*
- Toxicity Tests, Acute
- Zebrafish/physiology*
- PubMed
- 25545389 Full text @ Environ. Toxicol. Chem.
Citation
Boyle, D., Boran, H., Atfield, A., Henry, T.B. (2015) Use of an exposure chamber to maintain aqueous phase nanoparticle dispersions for improved toxicity testing in fish. Environmental toxicology and chemistry. 34(3):583-8.
Abstract
A novel chamber for maintaining aqueous phase dispersions of nanoparticles (NPs) to enable improved toxicity testing in larval zebrafish was developed. Aqueous concentrations were within 80% of initial NP concentrations, and 96-h LC50 values were highly reproducible (coefficient of variation <0.16, n=3 tests). Significantly lower toxicity for each NP tested (Ag-, Cu-, TiO2 -NPs) in static beakers suggested that traditional acute toxicity tests may underestimate aqueous phase toxicity of NPs. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping