PUBLICATION
Choroid plexus in developmental and evolutionary perspective
- Authors
- Bill, B.R., Korzh, V.
- ID
- ZDB-PUB-141203-40
- Date
- 2014
- Source
- Frontiers in neuroscience 8: 363 (Review)
- Registered Authors
- Bill, Brent, Korzh, Vladimir
- Keywords
- brain-CSF, epithelium, glia, stroma, transgenics, vasculature
- MeSH Terms
- none
- PubMed
- 25452709 Full text @ Front. Neurosci.
Citation
Bill, B.R., Korzh, V. (2014) Choroid plexus in developmental and evolutionary perspective. Frontiers in neuroscience. 8:363.
Abstract
The blood-cerebrospinal fluid boundary is present at the level of epithelial cells of the choroid plexus. As one of the sources of the cerebrospinal fluid (CSF), the choroid plexus (CP) plays an important role during brain development and function. Its formation has been studied largely in mammalian species. Lately, progress in other model animals, in particular the zebrafish, has brought a deeper understanding of CP formation, due in part to the ability to observe CP development in vivo. At the same time, advances in comparative genomics began providing information, which opens a possibility to understand further the molecular mechanisms involved in evolution of the CP and the blood-cerebrospinal fluid boundary formation. Hence this review focuses on analysis of the CP from developmental and evolutionary perspectives.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping