PUBLICATION
Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration
- Authors
- Wan, J., Zhao, X.F., Vojtek, A., Goldman, D.
- ID
- ZDB-PUB-140930-8
- Date
- 2014
- Source
- Cell Reports 9(1): 285-97 (Journal)
- Registered Authors
- Goldman, Dan, Wang,Jin
- Keywords
- none
- MeSH Terms
-
- Animals
- Animals, Genetically Modified
- Cell Differentiation/physiology
- Cytokines/metabolism*
- Intercellular Signaling Peptides and Proteins/metabolism*
- Nerve Regeneration/physiology*
- Retina/injuries
- Retina/metabolism*
- Retina/physiology*
- STAT3 Transcription Factor/metabolism*
- Signal Transduction
- Zebrafish
- Zebrafish Proteins/metabolism*
- beta Catenin/metabolism*
- PubMed
- 25263555 Full text @ Cell Rep.
Citation
Wan, J., Zhao, X.F., Vojtek, A., Goldman, D. (2014) Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration. Cell Reports. 9(1):285-97.
Abstract
Müller glia (MG) in the zebrafish retina respond to retinal injury by generating multipotent progenitors for retinal repair. Here, we show that Insulin, Igf-1, and fibroblast growth factor (FGF) signaling components are necessary for retina regeneration. Interestingly, these factors synergize with each other and with heparin-binding EGF-like growth factor (HB-EGF) and cytokines to stimulate MG to generate multipotent progenitors in the uninjured retina. These factors act by stimulating a core set of signaling cascades (Mapk/Erk, phosphatidylinositol 3-kinase [PI3K], β-catenin, and pStat3) that are also shared with retinal injury and exhibit a remarkable amount of crosstalk. Our studies suggest that MG both produce and respond to factors that stimulate MG reprogramming and proliferation following retinal injury. The identification of a core set of regeneration-associated signaling pathways required for MG reprogramming not only furthers our understanding of retina regeneration in fish but also suggests targets for enhancing regeneration in mammals.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping