PUBLICATION

Tolerance and Efficacy of Emamectin Benzoate and Ivermectin for the Treatment of Pseudocapillaria tomentosa in Laboratory Zebrafish (Danio rerio)

Authors
Collymore, C., Watral, V., White, J.R., Colvin, M.E., Rasmussen, S., Tolwani, R.J., Kent, M.L.
ID
ZDB-PUB-140923-18
Date
2014
Source
Zebrafish   11: 490-7 (Journal)
Registered Authors
Kent, Michael
Keywords
none
MeSH Terms
  • Animals
  • Antinematodal Agents/adverse effects
  • Antinematodal Agents/pharmacology*
  • Antinematodal Agents/therapeutic use
  • Enoplida Infections/drug therapy
  • Enoplida Infections/parasitology
  • Enoplida Infections/veterinary*
  • Female
  • Fish Diseases/drug therapy*
  • Fish Diseases/parasitology
  • Ivermectin/adverse effects
  • Ivermectin/analogs & derivatives*
  • Ivermectin/pharmacology*
  • Ivermectin/therapeutic use
  • Male
  • Trichuroidea/drug effects*
  • Zebrafish*
PubMed
25237985 Full text @ Zebrafish
Abstract
Tolerance of adult zebrafish and efficacy of emamectin benzoate and ivermectin in eliminating Pseudocapillaria tomentosa infection were evaluated. In the tolerance study, behavioral changes, fecundity, histopathology, and mortality were evaluated for in-feed administration of emamectin (0.05, 0.10, and 0.25 mg/kg) and ivermectin (0.05 and 0.10 mg/kg). All doses of emamectin were well tolerated. Ivermectin 0.05 mg/kg administration resulted in mild behavioral changes and a transient decrease in fecundity. Ivermectin 0.10 mg/kg administration resulted in severe behavioral changes and some mortality. In the efficacy study, emamectin (0.05 and 0.25 mg/kg) and ivermectin (0.05 mg/kg) were evaluated for their efficacy in eliminating P. tomentosa infection. Emamectin reduced parasite burden in infected zebrafish, and ivermectin eliminated intestinal nematode infections. Despite a small margin of safety, ivermectin 0.05 mg/kg was effective at eliminating P. tomentosa infection in adult zebrafish. Higher doses or a longer course of treatment may be needed for complete elimination of P. tomentosa infection using emamectin. In this study, we propose two possible treatments for intestinal nematode infections in zebrafish.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes